Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

Article Abstract:

Research presented concerns the function of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), focusing on the protein's role in suppressing tumor metastasis. Researchers examine the physiological aspects of TRAIL expression on murine natural killer cells in the liver.

Japan, Statistical Data Included, Physiological aspects, Cell death, Metastasis, Cancer metastasis, Tumor necrosis factor, Killer cells

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Eradication of established tumors in mice by a combination antibody-based therapy

Article Abstract:

A combination therapy of three monoclonal antibodies (trimAB) is used to induce tumor-specific T cells, which are the principal effectors of successful antitumor immunotherapies in mice. The results indicate that a rational monoclonal antibody-based therapy that both causes tumor-cell apoptosis through DR5 and activates T cells may be an effective strategy for cancer immunotherapy in humans.

United States, Science & research, HEALTH SERVICES, Cancer Therapy, Ambulatory Health Care Services, Care and treatment, Cancer, Cancer treatment, T cells, Monoclonal antibodies, Tumours

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Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 'killer' dendritic cells

Article Abstract:

Killer dendritic cells (DCs) might be useful as immunosuppressive agents. Normally, DCs activate T cells in the presence of an antigen. Killer DCs have been created that contain the CD95 ligand, which destroys T cells after antigen-specific activation.

Immunosuppressive agents, Antigen presenting cells

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