Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells
Article Abstract:
Research presented concerns the function of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), focusing on the protein's role in suppressing tumor metastasis. Researchers examine the physiological aspects of TRAIL expression on murine natural killer cells in the liver.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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Eradication of established tumors in mice by a combination antibody-based therapy
Article Abstract:
A combination therapy of three monoclonal antibodies (trimAB) is used to induce tumor-specific T cells, which are the principal effectors of successful antitumor immunotherapies in mice. The results indicate that a rational monoclonal antibody-based therapy that both causes tumor-cell apoptosis through DR5 and activates T cells may be an effective strategy for cancer immunotherapy in humans.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 'killer' dendritic cells
Article Abstract:
Killer dendritic cells (DCs) might be useful as immunosuppressive agents. Normally, DCs activate T cells in the presence of an antigen. Killer DCs have been created that contain the CD95 ligand, which destroys T cells after antigen-specific activation.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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