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Longitudinal evaluation and risk factors of lipodystrophy and associated metabolic changes in HIV-infected children

Article Abstract:

A study was conducted to assess the rate of progression of lipodystrophy and the associated metabolic disturbances over a 2-year period in children and to assess risk factors associated with lipodystrophy and metabolic disturbances. The observations indicate that puberty seems to be the time when children are most likely to develop lipodystrophy and metabolic complications, especially in children with severe underlying HIV infection.

Complications and side effects, Risk factors, Antiviral agents, Antiretroviral agents, Lipodystrophy, Disease/Disorder overview

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A 12-month treatment with tenofovir does not impair bone mineral accrual in HIV-infected children

Article Abstract:

A study that was carried out to assess whether the substitution to stavudine (d4T) with short term use of tenofovir (TDF) would result in decreased bone mineral content and bone mineral density accrual in HIV-infected children is discussed. It is observed that substitution to a TDF-containing antiretroviral regimen does not impair bone mineral accrual in children showing a good immunologic response to antiretroviral treatment.

Usage, Bones, Bone density, Tenofovir

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Disease progression among HIV-infected children who receive perinatal zidovudine prophylaxis

Article Abstract:

A population-based cohort of children with perinatal HIV infection is used to examine the effect of perinatal zidovudine prophylaxis (PZP) on early disease progression among infants with breakthrough perinatal HIV infection. The analysis has suggested that HIV-infected children receiving PZP started antiretroviral therapy (ART) at an early age and has shown decreased HIV disease progression by the age of 3 years.

United States, Development and progression, Children, Child health, Zidovudine, Clinical report

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