Loss of p14(sup)ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015)

Article Abstract:

Results demonstrate that in the absence of the tumor suppressor protein p14(sup)ARF, the adenovirus mutant dl1520 is able to replicate in wild-type tumor cells containing p53. Data also show that the therapeutic use of the mutant in tumors is feasible when p53 pathway has only a genetic lesion other than a mutation.

Growth, Viruses, Tumors

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An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

Article Abstract:

Adenoviruses infect and replicate in quiescent cells by inducing S-phase entry mediated by viral proteins. Gene-attenuated adenoviruses are employed as selectively replicating anti-tumoral agents as shown by the E1A mutant. Data indicate that the mutant exhibits even stronger potency than the wild-type and reduces metastasis of breast tumor.

Breast cancer, Antineoplastic agents, Cancer metastasis

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Induction of an oncogenic fusion protein by a viral gene -- a new chapter in an old story

Article Abstract:

Researchers report that adenovirus can create an oncogenic fusion protein identical to the one that causes Ewing's sarcoma. This supports the possible role of viruses in the creation of cancer.

Causes of, Cancer

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