Measurement of joint inflammation in rheumatoid arthritis with indium-111 chloride
Studies using animal models of arthritis, the inflammation of the joints, show that a radioactive imaging technique called indium-111 chloride scintigraphy can measure the degree of joint inflammation. Indium-111 chloride scans were performed on 21 patients with rheumatoid arthritis (RA), a disorder characterized by inflammation of the joints, swelling, stiffness, overgrowth of cartilage, and pain. Clinical symptoms of the disease were assessed independently of the scan results. Indium-111 chloride scintigraphy and clinical evaluation were also carried out in eight patients with osteoarthritis, a long-term disease of the joints, characterized by destruction of joint cartilage and overgrowth, malformation, and decreased function of the bone. Among patients with RA, there was a correlation between the uptake of indium-111 chloride by the joint and the extent of swelling, pain, and abnormalities of the joint. Among patients with osteoarthritis, joint uptake of indium-111 chloride was related to the degree of joint pain. In addition, measures of radioactive uptake by the joint were associated with the number of swollen joints and decreasing grip strength among patients with RA. Patients with osteoarthritis showed less joint uptake of the radioactive substance than patients with RA. Thus, indium-111 chloride scanning was shown to be effective in measuring joint abnormalities in RA. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Annals of the Rheumatic Diseases
An 81-year-old woman with temporal arteritis
The case of an 81-year-old female patient whose left temporal artery showed active giant cell arteritis with intimal edema is presented. A clinician discusses the occurrence and diagnosis of temporal arteritis, and also recommends a line of treatment for the specified case.
Publication Name: JAMA, The Journal of the American Medical Association
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