Microarray analysis and tumor classification
Deoxyribonucleic acid (DNA) microarray analysis was first described as a means to probe the expression of thousands of genes simultaneously and the technique was soon adopted to search for patterns of expression that could be used to classify types of tumors and predict the outcome and response to chemotherapy. A review of some of the basic issues related to the use of microarray data is presented, including the potential limitations of their use.
Publication Name: The New England Journal of Medicine
Tumor-induced osteomalacia (TIO) is illustrated by the clinical presentation of a 55-year-old female patient with progressive fatigue, weakness, and muscle and bone pain with fractures. The distinctive clinical characteristics of this syndrome, the advances in diagnosis of TIO, and new insights into the pathophysiology of this disorder are discussed.
Publication Name: JAMA, The Journal of the American Medical Association
What is a tumor promoter?
Tumor promoters, which are non-DNA reactive carcinogens, are discussed in relation to assessment of drug and chemical safety and risk. Topics include the use of transgenic mouse models and the two-stage assay to identify tumor promoters.
Publication Name: Environmental Health Perspectives
- Abstracts: Medical, Legal, and Societal Implications of Androstenedione Use. Creatine and androstenedione -- two "dietary supplements."
- Abstracts: Essential fatty acids and inflammation. Novoseven for non-hemophilia hemostasis
- Abstracts: Alcohol and health: The pros and the cons. Alcohol: caution is advised. On a binge: women and alcohol on campus
- Abstracts: Economic analysis of health care technology: a report on principles. Capillary hemangioma of the endometrium: a case report and review of the literature
- Abstracts: Insanity as a result of hysterotomy and oophorectomy. Harvesting monoclonal antibodies from plants. Predicting heat worldwide