Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
Article Abstract:
The new components regulating the inflammatory cascade during sepsis are identified by characterizing the functions of myeloid-related protein-8 (Mrp8, S100A8) and myeloid-related protein-14 (Mrp14, A100A9), two abundant cytoplasmic proteins of phagocytes. The analysis has shown that Mrp8-Mrp14 complexes are new inflammatory components that have amplified phagocyte activation during sepsis upstream of Toll-like receptor [alpha] (TNF[alpha])-dependent effects.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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Activation of [[beta].sub.2]-adrenergic receptor stimulates [gamma]-secretase activity and accelerates amyloid plaque formation
Article Abstract:
A study suggests that activation of [[beta].sub.2]-adrenergic receptor ([[beta].sub.2]-AR) enhances [gamma]-secretase activity resulting in increased A[beta] production. The [[beta].sub.2]-AR activation could stimulate [gamma]-secretase activity and amyloid plaque formation that suggests that abnormal activation of [[beta].sub.2]-AR might contribute to A[beta] accumulation in Alzheimer disease pathogenesis.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Increased sensitivity to the stimulant effects of morphine conferred by anti-adhesive glycoprotein SPARC in amygdala
Article Abstract:
Research demonstrates that the locomotor sensitization of the basolateral amygdala is induced by morphine through the secreted protein acidic and rich in cysteine (SPARC) glycoprotein in the amygdala. Data further show that mice with no previous morphine exposure show substantial increase in the locomotor activity after SPARC infusion followed by morphine injection.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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