Abstracts » Health

Multicenter, comparative study of enoxacin and ceftriaxone for treatment of uncomplicated gonorrhea

Article Abstract:

Neisseria gonorrhoeae is a class of bacteria causing the sexually transmitted disease gonorrhea. Gonorrhea is treated with antibiotic drug therapy. However, some strains of gonorrhea bacteria have changed genetically and have become resistant to penicillin and tetracycline, once the antibiotic drugs of choice. The development of tetracycline-resistant neisseria gonorrhoeae (TRNG) has decreased routine tetracycline use in the treatment of gonorrhea. Ceftriaxone, the current drug of choice against TRNG, and a new antibiotic, enoxacin, were compared for efficacy in the treatment of 152 TRNG-infected patients. Gonorrheal infections usually affect the genital area and the throat (pharyngeal gonorrhea). Genital gonorrhea was cured in 75 of the 76 patients receiving enoxacin and 73 of the 75 patients receiving ceftriaxone. The cases of pharyngeal gonorrhea were cured by ceftriaxone but not by enoxacin. A single oral dose of 400 mg of enoxacin was considered a safe and effective alternative therapy for the treatment of uncomplicated genital gonorrhea caused by TRNG.

Causes of, Drug resistance in microorganisms, Microbial drug resistance, Tetracycline, Tetracyclines, Ceftriaxone sodium

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Single dose enoxacin for the treatment of uncomplicated urogenital gonorrhea

Article Abstract:

In various dosing regimens, Enoxacin, an antibiotic effective against a wide range of microorganisms, is an effective treatment for uncomplicated gonorrhea, including strains that are resistant to penicillin (antibiotic). The safety and effectiveness for treating genital gonorrhea with 400 milligrams of oral enoxacin was compared with the effectiveness of treatment with 250 milligrams of ceftriaxone (antibiotic) injected into the muscles. Twenty-six men and 22 women with gonorrhea bacteria in the genital area were studied. Six patients had strains of the bacteria resistant to penicillin, and 11 patients also had chlamydia (genital infection). The bacteria was successfully eradicated from the genitals of 96 percent of patients treated with enoxacin and all the patients treated with ceftriaxone. Neither drug had side effects. Therefore, it is concluded that oral enoxacin is a safe and effective means of treating genital gonorrhea infections.

Sexually transmitted diseases, Antibiotics

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Comparison of enoxacin and ceftriaxone in the treatment of uncomplicated gonorrhea

Article Abstract:

Enoxacin may be as effective and safe as ceftriaxone for the treatment of gonorrhea. Gonorrhea is a sexually transmitted disease caused by the bacterium Neisseria gonorrhoeae. Among 59 male and female patients with gonorrhea, 29 were treated with 400 milligrams (mg) of enoxacin and 30 were treated with 250 mg of ceftriaxone. Only one patient in each treatment group did not respond to treatment. Both patients who did not respond to treatment were women with a cervical infection. Only two patients treated with enoxacin experienced any side effects. None of the patients treated with ceftriaxone had any side effects. Neither drug was an effective treatment for a simultaneous infection caused by Chlamydia trachomatis.

Health aspects

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