Nitric oxide (NO) chemical activity seems to affect the functioning of many systems of the body, including the immune system, heart, brain, and intestinal tract. Researchers presented evidence of NO action in these bodily systems, the chemical pathways to explain these actions, and implications for patients with rheumatic diseases. NO plays a role in dilating blood vessels and preventing blood cells from clotting. The effects of NO on the nervous system can be either protective or toxic depending on the gas' chemical state. NO may also play a role in the brain's learning processes and in the immune system's inflammatory processes, particularly in response to organ transplants, rheumatic diseases, cancers, and bacterial or viral infections. Evidence suggests that NO production, in combination with low oxygen levels and high acid levels, may lead to joint damage.
Publication Name: Annals of the Rheumatic Diseases
The effect of peroxides and free radicals on body tissues
Most tooth bleaching agents contain hydrogen peroxide. Hydrogen peroxide is formed naturally in the body as a consequence of oxygen metabolism. However, it is present in very small quantities and the body has several mechanisms for eliminating it. These include enzymes such as catalase, peroxidase and superoxide dismutase. The body also produces antioxidants such as vitamin E, vitamin C and glutathione. In addition to the low-level oxidative stress produced by the body, external agents can cause moderate to intense oxidative stress.
Publication Name: Journal of the American Dental Association
Effect of fluoroquinolone on the enhanced nitric oxide-induced peripheral vasodilation seen in cirrhosis
Norfloxacin treatment appears to reverse the effects on blood flow caused by nitric oxide formation among patients with liver cirrhosis. Blood flow measurements were performed on 10 healthy volunteers (the control group) and nine patients with liver cirrhosis treated with or without norfloxacin. Blood flow in untreated patients was significantly higher than in the control group but decreased to near normal levels after treatment. Blood levels of a marker of nitric oxide formation decreased after treatment.
Publication Name: Annals of Internal Medicine
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