Nitric oxide and cyclic GMP in cell signaling and drug development

Article Abstract:

Research work related to the nitric oxide and cyclic guanosine monophosphate (GMP) signaling pathways and its role as a messenger in regulating some biochemical and physiological functions is presented. Cyclic GMP could regulate cation channels, cyclic GMP-dependent protein kinases, and some isoforms of phosphodiesterase and each of the molecular sites in these pathways could become an obvious target for new drugs used as single agents.

Cyclic guanylic acid, Cyclic guanosine monophosphate, Phosphodiesterases

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Early inhaled nitric oxide therapy in premature newborns with respiratory failure

Article Abstract:

A randomized trial was conducted to understand the safety and efficacy of early, low-dose, prolonged therapy with inhaled nitric oxide in premature new born babies with respiratory failure. Low-dose inhaled nitric oxide did not reduce the overall incidence of bronchopulmonary dysplasia in premature newborns with respiratory failure and birth weight less than 1000 g, but it reduced the overall risk of brain damage.

Health aspects, Risk factors, Infants (Premature), Premature infants, Respiratory insufficiency, Disease/Disorder overview

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Ozone: from environmental pollutant to atherogenic determinant

Article Abstract:

P. Wentworth Jr., and his colleagues from the Boston University School of Medicine, Boston, has come up with an observation, which shows that one of the derivatives of molecular oxygen is found in vascular disorder atherosclerosis. Another discovery made by Wentworth and team in the arteries of humans is the ozone.

Oxygen, Atherosclerosis, P. Wentworth Jr.

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