Protecting the female germ line from cancer therapy

Article Abstract:

An innovative approach to prevent premature ovarian failure and oocyte destruction in women after chemotherapy and radiotherapy for cancer is discussed. Research reveals that small lipid molecules, sphingosine-1-phosphates, have shown promise in arresting apoptosis of mouse oocytes after treatment for cancer.

Canada, Germ cell tumors, Germinoma, Cancer, Chemotherapy

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Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy

Article Abstract:

Research reveals that manipulation of the gene encoding sphingomyelinase to attack fetal cells in vivo and sphingosine-1-phosphate treated oocytes in vitro result in the suppression or resistance to apoptosis. Implications of this finding in preventing oocyte loss or female infertility by in vivo therapy with sphingosine-1-phosphate are discussed.

Statistical Data Included, Usage, Fertility

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ATM regulates target switching to escalating doses of radiation in the intestines

Article Abstract:

A study revealed that when mouse intestines were protected against microvascular apoptosis, radiation switched as the dose escalated to a previously unrecognized crypt stem cell target, activating ceramide synthase-mediated apoptosis to initiate intestinal damage. It indicated that tissues operate multiple potential targets activated consecutively according to their inherent radiosensitivities that may be reordered therapeutically to control radiation tissue responses.

Science & research, Research, Ataxia telangiectasia, Apoptosis

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