Oral fingolimod (FTY720) for relapsing multiple sclerosis
Article Abstract:
A double-blind, placebo-controlled, proof-of-concept clinical study is conducted to evaluate the efficacy and safety of fingolimod (FTY 720), an oral immunomodulating agent for the treatment of relapsing multiple sclerosis. Results suggest that fingolimod reduces the number of lesions detected on MRI and clinical disease activity in patients with multiple sclerosis, but larger-scale, longer-term clinical studies are necessary for further evaluation of its benefits and risks.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
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Prognostic significance of autoimmunity during treatment of melanoma with interferon
Article Abstract:
The prognostic significance of autoimmunity in patients with stage IIB, IIC, or III melanoma who were treated with high-dose adjuvant interferon alfa-2b is assessed. The appearance of autoantibodies or clinical manifestations of autoimmunity during the treatment with interferon alfa-2b is associated with statistically significant improvements in relapse-free survival and overall survival in patients with melanoma.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
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Molecular aspects of the transport and toxicity of ochratoxin A
Article Abstract:
A new molecular insight into transport and activation of ochratoxin A (OTA) is discussed. The lifetime of OTA in living systems is dependent on the presence of serum albumin.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2004
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