Outcome of infants with birth weight less than 1000g with respiratory distress syndrome treated with high-frequency ventilation and surfactant replacement therapy
Article Abstract:
Very low birthweight infants with respiratory distress syndrome may be successfully treated with high-frequency ventilation and surfactant therapy. A study of 114 premature infants weighing less than 1000 grams found that even though infants receiving high-frequency ventilation (HFV) were smaller and more premature than infants receiving conventional mechanical ventilation, the HFV group did not have higher incidences of intraventricular hemorrhage or impaired neurodevelopmental outcome. The Infant Star High Frequency Ventilator used in this study allows for sigh breaths and a fixed inspiratory time of 18 seconds to avoid incomplete exhalation and overinflation of the lungs. HFV and surfactant therapy may need to be initiated soon after birth to further reduce complications.
Publication Name: Archives of Pediatrics & Adolescent Medicine
Subject: Health
ISSN: 1072-4710
Year: 1995
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Postconceptional age of surviving preterm low-birth-weight infants at hospital discharge
Article Abstract:
Post-conceptual age may be a better indicator of expected hospital stays for premature, low-birth-weight infants than charts currently in use. Post-conceptual age is an infant's age since conception. Researchers studied the medical records of 960 premature, low-birth-weight infants to determine whether there was a consistent association between post-conceptual age of these infants and the length of their hospital stay. Infants weighing more than 1500 grams (g) at birth typically stayed in the hospital until they reached the post-conceptual age of 36 weeks. Infants who weighed less than 1500 g at birth or who had added complications such as brain, lung, or stomach disorders had longer hospital stays.
Publication Name: Archives of Pediatrics & Adolescent Medicine
Subject: Health
ISSN: 1072-4710
Year: 1996
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Birth weight and age-specific analysis of the 1990 US infant mortality drop: was it surfactant?
Article Abstract:
The widespread introduction of surfactant in 1989 may have played a role in the drop in infant death rates in 1990, but other factors also were involved. Premature infants lack surfactant, which is a fluid that lines the lungs. Instilling it into their lungs at birth helps them breathe. Researchers analyzed national infant death rate data by birth weight. More infants weighing 750 to 1,749 survived than calculations predicted while the death rate for birth weights from 1,750 to 2,499 grams was as predicted. However, fewer infants weighing 2,500 grams or more died than predicted, and this cannot be attributed to surfactant.
Publication Name: Archives of Pediatrics & Adolescent Medicine
Subject: Health
ISSN: 1072-4710
Year: 1997
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