Abstracts » Health

Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome

Article Abstract:

D-chiro-inositol supplements may improve the prognosis of polycystic ovary syndrome. This syndrome is characterized by defects in ovulation, insulin metabolism and other metabolic abnormalities. Researchers randomly assigned 44 obese women with the syndrome to take D-chiro-inositol or a placebo every day for 6 to 8 weeks. D-chiro-inositol is a naturally occurring chemical in the body that is stimulated by insulin. Nineteen of the 22 women taking D-chiro-inositol ovulated compared to only 6 of the 22 taking placebo. Women on D-chiro-inositol also had lower blood pressure, lower testosterone levels, and lower triglyceride levels.

Health aspects, Care and treatment, Inositol

---

Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome

Article Abstract:

Obese women with the polycystic ovary syndrome can increase their chances of becoming pregnant when given clomiphene to induce ovulation if they take metformin. Polycystic ovary syndrome is a common cause of infertility in women and can often cause insulin resistance. Researchers randomly assigned 61 obese women with the polycystic ovary syndrome to take the insulin-lowering drug metformin or a placebo for 35 days. They were then given clomiphene to induce ovulation. Eighty-nine percent of the women who took metformin ovulated compared to 12% of the women who took a placebo.

Evaluation, Clomiphene

---

Decreases in ovarian cytochrome P450c17alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome

Article Abstract:

Lowering high blood insulin levels in women with polycystic ovary syndrome could lower their blood levels of testosterone and relieve their symptoms. Women with polycystic ovary syndrome also have increased activity of the P450c17alpha enzyme, which converts the female hormone progesterone into testosterone. Researchers gave 11 women with polycystic ovary syndrome metformin, which lowers blood insulin. This lowered their insulin levels and also the activity of the enzyme. This led in turn to lower testosterone levels.

Physiological aspects, Testosterone, Insulin

Some parts © 2012 Advameg, Inc.