Perfusion thallium imaging of type I diabetes patients with end stage renal disease: comparison of oral and intravenous dipyridamole administration
Article Abstract:
People with type I diabetes are prone to developing coronary artery disease, kidney disease, and other complications. They sometimes require kidney transplants when severe kidney disease develops. If these patients also suffer from severe coronary artery disease, transplant surgery is often not recommended. Patients who are candidates for transplantation or who have already undergone it are screened for coronary artery disease. A perfusion thallium treadmill stress test is often done for this purpose; the drug dipyridamole is given during this procedure. Dipyridamole is presently given in oral form, and it is thought that the test results might be compromised because absorption of drugs given orally is variable, especially in diabetic patients. This study examined whether coronary artery disease could be more accurately diagnosed if the dipyridamole were given intravenously rather than orally. Dipyridamole-thallium-201 scintigraphy was performed in 80 diabetic patients with kidney disease; half received dipyridamole orally, and half received it intravenously. Coronary angiography, a technique for visualizing the blood vessels, was also performed as the standard for diagnosing coronary artery disease. Results showed that no severe side effects occurred with either method of administering dipyridamole, and the two methods were equally accurate in diagnosing disease. When results for the two groups were combined, the overall accuracy was 83 percent in detecting coronary artery disease. These results indicate that oral and intravenous dipyridamole administration are equally effective in a perfusion thallium imaging test for coronary artery disease. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Radiology
Subject: Health
ISSN: 0033-8419
Year: 1990
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Incidental fibromuscular dysplasia in potential renal donors: long-term clinical follow-up
Article Abstract:
Individuals under consideration as kidney donors are given comprehensive physical examinations. In the course of evaluating 1,862 persons for this procedure, 71 individuals, or 3.8 percent, were found to have fibromuscular thickening of their renal artery walls, fibromuscular dysplasia (FMD). Ultimately 19 of the FMD patients were used as donors, 30 were rejected, and 19 were lost to follow-up. This paper follows the long-term development of hypertension (high blood pressure) in those patients who donated their kidney and those who were rejected. The findings were also compared to a control group of normal individuals in the same age group. Twenty-six percent of individuals who were found to have FMD, but had normal blood pressure at the time of being worked up for kidney donation, ultimately developed hypertension. The rate of hypertension in the control group was only six percent. The evidence strongly suggests that the development of hypertension in middle-aged patients with FMD is statistically higher than for similarly-aged healthy individuals.
Publication Name: Radiology
Subject: Health
ISSN: 0033-8419
Year: 1989
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Double-lumen needle for percutaneous ureteral pressure-flow studies
Article Abstract:
This study investigated the use of a double-lumen, or two opening, needle for gaining access to the kidneys in patients who had no previous needle access site. This is one of the most important ways of establishing the effectiveness of blood flow to and from the kidneys. The double-lumen for percutaneous ureteral pressure flow studies is used to gauge measurements of blood perfusion and pressure within the kidneys in patients suffering from partial ureteral obstruction. The technique has proven to be both a safe and effective with a single, small gauge needle. The use of this needle has been especially effective in patients with transplanted kidneys. The single access site allowed by the use of this needle is one of its main benefits.
Publication Name: Radiology
Subject: Health
ISSN: 0033-8419
Year: 1989
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