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Perinatal exposure to zidovudine - benefits and risks

Article Abstract:

The in utero or neonatal exposure of children to antiretroviral agents to protect them from HIV infection is getting much attention from both the developed and under developed countries. In the United States, substantial progress is made in eliminating new perinatal infections with zidovudine antiretroviral prophylaxis in HIV-infected pregnant women. The safety of such an in utero exposure to zidovudine has been recently documented in that no acute or chronic abnormalities of cardiac structure or function was noted. However, some studies have been contradictory, so additional research is merited.

Editorial, Evaluation, Complications and side effects, HIV infections, Pregnancy, Antiviral agents, Zidovudine, HIV infection in pregnancy

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Fetal pulse oximetry and cesarean delivery

Article Abstract:

A randomized trial was designed to evaluate the effectiveness and safety of fetal oximetry with primary objective to determine whether fetal oximetry as a conventional electronic fetal monitoring would result in a reduction in the overall rate of cesarean deliveries and potential side effects to both mother and the neonate. The knowledge of the fetal oxygen saturation is not associated with a reduction in the rate of cesarean delivery or with improvement in the condition of the newborn.

Electromedical and Electrotherapeutic Apparatus Manufacturing, Electromedical equipment, Blood-Gas Monitors, Usage, Cesarean section, Oximetry, Blood gas monitors

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Combination therapy with efavirenz, nelfinavir, and nucleoside reverse-transcriptase inhibitors in children infected with human immunodeficiency virus type 1

Article Abstract:

The AIDS drugs efavirenz and nelfinavir appear to be beneficial in children with HIV infection. Researchers gave this treatment to 57 HIV-infected children who had previously been treated with nucleoside reverse transcriptase inhibitors. Efavirenz is a non-nucleoside reverse transcriptase inhibitor and nelfinavir is a protease inhibitor. After one year of treatment, 63% of the children had very low blood levels of the virus.

HIV infection in children, Pediatric HIV infections

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