Longitudinal changes in body composition measured with a variety of methods in patients with AIDS

Article Abstract:

Weight loss in HIV patients appears to involve mostly the loss of fat-free mass (FFM). This indicates that it is a result of starvation rather than a hypermetabolic state. Researchers used four methods to measure changes in body composition in 21 AIDS patients: skinfold thickness (SF), dual-energy X-ray absorptiometry (DEXA), total body water (TBW) and bioelectrical impedance (BIA). The percentage of FFM lost ranged from 55% to 60% using SF, DEXA and TBW but averaged 65% to 78% using BIA. BIA may overestimate FFM loss depending on what prediction equation is used.

Measurement, Complications and side effects, Physiological aspects, Body composition, Weight loss, AIDS (Disease), Cachexia

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Studies of antiretroviral therapy in the Multicenter AIDS Cohort Study

Article Abstract:

The Multicenter AIDS Cohort Study, begun in 1984, is a collaborative study by four medical centers of 5000 gay men infected with or at high risk for HIV. The study has provided important information about the natural history and progression of HIV infection and AIDS, and the effects of antiviral therapy. The drug AZT (zidovudine) has been associated with increased survival and a lower risk of developing AIDS dementia.

Evaluation, Prevention, Development and progression, HIV infection, HIV infections, Information services, HIV patients, Antiviral agents, Zidovudine, Information storage and retrieval systems, Medical statistics, AIDS dementia, AIDS dementia complex

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