Polymorphism in the LMP2 gene influences susceptibility to extraspinal disease in HLA-B27 positive individuals with ankylosing spondylitis
Article Abstract:
Variations in the LMP2 gene appear to play a role in the pathology of ankylosing spondylitis AS in HLA-B27-positive individuals. AS is an autoimmune disease causing degeneration of the spinal vertebral joints. It is generally accepted that persons expressing the tissue antigen group B27 are more likely to develop certain autoimmune diseases. However, other genes involved in antigen expression are also suspected of playing a role. A group of 193 HLA-B27-positive white individuals with AS and 49 similar Chinese individuals had blood samples taken for genetic analysis. Percentages of both populations additionally had arthritis in peripheral joints, eye inflammation episodes, or both. Forty-two healthy HLA-B27-positive blood donors served as controls. AS patients were more likely to have the same variant of the LMP2 gene on both chromosomal strands compared with healthy persons. AS patients with additional complications were more likely to carry this variant on both genes than AS patients not experiencing additional complications.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
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Matching prevalence of peripheral arthritis and acute anterior uveitis in individuals with ankylosing spondylitis
Article Abstract:
A group patients with both ankylosing spondylitis (AS) and with arthritis in peripheral joints as well as spinal joints were more likely to have an episode of acute anterior uveitis. Anterior uveitis is a type of eye inflammation. Data were analyzed from two populations. One set comprised 222 unrelated white individuals referred to rheumatologists in Edmonton, Canada. The other set comprised 29 unrelated Taiwanese patients. Patients had been followed an average of 18 years. Eighty-nine white patients had experienced acute anterior uveitis of whom 40% had arthritis in peripheral joints versus 25% of patients with no peripheral joint involvement. Seventy-nine percent of the Asian patients had peripheral arthritis, including all patients who had experienced acute anterior uveitis.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
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The LMP2 polymorphism is associated with susceptibility to acute anterior uveitis in HLA-B27 positive juvenile and adult Mexican subjects with ankylosing spondylitis
Article Abstract:
It appears that Mexicans with ankylosing spondylitis (AS) testing positive for HLA-B27 who carry different forms of the low-weight polypeptide-2 (LMP2) gene may be at increased risk of developing an eye disease called acute anterior uveitis (AAU). Ankylosing spondylitis is a spinal disease. Blood samples from 80 patients from Mexico City who developed AS as a child and 90 patients from Guadalajara who developed AS as adults were analyzed for LMP2. Significantly more patients from either city with AAU carried the LMP2A form than people from the general city population without AAU. Age when AS began was not a factor.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1997
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