Positive correlation between the natural killer and gp120/41-specific antibody-dependent cellular cytotoxic effector functions in HIV-infected individuals
Article Abstract:
A statistical model that correlates the natural killer (NK) activity of certain blood cells with an antibody activity may predict the strength of these activities in people with HIV. Predicting these activities may provide insight into their role in the immune response to HIV and AIDS. Researchers used an existing model to measure the antibody-dependent ability of peripheral blood mononuclear cells (PBMC) to kill viruses in 39 people with HIV type 1. They also measured the NK activity of the PBMC and found that the strength of these two activities was positively related. A decrease in the NK activity of PBMC correlated with a decrease in the antibody-dependent ability to kill viruses, hence a less effective immune response to HIV and AIDS.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1995
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Increased numbers of granzyme-B-expressing cytotoxic T-lymphocytes in the small intestine of HIV-infected patients
Article Abstract:
Many HIV-infected patients have increased levels of cytotoxic T cells in their intestinal mucosa, but the presence of activated T cells does not appear to be linked to diarrhea. Intestinal biopsy samples from 29 HIV-infected patients and 15 healthy volunteers were stained for T cells expressing granzymes, which are granule-associated enzymes. Twenty-two of the HIV-infected patients had granzyme-positive T cells, which is a sign of T cell activation. Only two of the healthy participants had activated T cells in the intestine. HIV-infected patients without diarrhea were just as likely to have activated T cells as those with diarrhea.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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Serial CD4 and CD8 T-lymphocyte counts and associated mortality in an HIV-2-infected population in Guinea-Bissau
Article Abstract:
Infection with HIV-2 does not seem to have as severe an impact on the immune system as infection with HIV-1. Researchers followed 47 people who were HIV-2-positive and 82 people who were HIV-2-negative (the control group) from 1988 to 1992. Regular blood tests revealed that HIV-2 did not have a profound effect on the immune system. The only difference between the HIV-2-positive group and the control group is that those who were HIV-2-positive experienced a drop in their CD4 cell counts. The 8 HIV-2-positive individuals who died had no significant differences in immune function compared to those who survived.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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