Preliminary results of early clinical trials with the fully human anti-TNFalpha monoclonal antibody D2E7

Article Abstract:

The pharmaceutical company BASF Pharma has developed a monoclonal antibody against tumor necrosis factor that contains human elements. Most monoclonal antibodies are made in mice, but humans could have an immune reaction to the antibody when it is used therapeutically. BASF Pharma's antibody appears to be effective in patients with rheumatoid arthritis.

Product development, BASF Pharma

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Immunomodulation by thalidomide and thalidomide analogues

Article Abstract:

Drugs derived from thalidomide may be effective in treating diseases caused by excessive levels of tumor necrosis factor. Tumor necrosis factor is an immune system protein that causes inflammation and it has been implicated in the development of rheumatoid arthritis. These drugs block the activity of tumor necrosis factor.

Thalidomide

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Anti-TNF antibody treatment of Crohn's disease

Article Abstract:

A drug called infliximab may be effective in treating Crohn's disease. Crohn's disease is an inflammation of the intestines and infliximab blocks the activity of an inflammatory immune system protein called tumor necrosis factor.

Crohn's disease

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