Prevalence, incidence, and estimated life-time risk of cervical human papillomavirus infections in a nonselected Finnish female population
Article Abstract:
Human papillomavirus infections (genital warts) can cause changes in the cells of cervix, which can lead to cervical cancer. The incidence if HPV viral infections, thought to be transmitted sexually, has been increasing steadily. Pap smears performed during routine gynecological examinations can be evaluated for the human papillomavirus (HPV). In a population of 22-year-old Finnish women, 2,084 Pap smears were evaluated for HPV infections. To estimate the lifetime risk of cervical HPV infections, 1,289 women agreed to enter the study. At one year follow-up 1,069 women were rescreened for the virus. The number of cases of HPV infections was three percent at the initial screening and seven percent at follow-up one year later. The annual incidence of HPV infections in this group was seven percent. It is estimated that half of the sexually active women will have at least one HPV infection within 10 years, and 79 percent will have had at least one HPV infection during their lifetime. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Sexually Transmitted Diseases
Subject: Health
ISSN: 0148-5717
Year: 1990
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Vertical transmission of human papillomavirus from infected mothers to their newborn babies and persistence of the virus in childhood
Article Abstract:
Pregnant women infected with human papillomavirus (HPV) may transmit the virus to their infants during vaginal delivery. Researchers examined 98 children of 66 HPV-infected mothers for evidence of mouth lesions and warts on the hands. HPV was detected in scrapings of mouth tissue in 31 of the children (31.6%). Mouth tissue in 22 of the children (22.4%) exhibited abnormal overgrowth of tissue. Five children whose mothers had HPV genital lesions at the time of delivery had the same HPV type as their mothers. Twenty-five children did not have oral HPV, and their mothers were negative for HPV at the time of delivery. It is not known whether children who acquire HPV as infants have a greater risk of developing oral cancer.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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Mutation of tumor suppressor gene p53 is frequently found in vulvar carcinoma cells
Article Abstract:
Mutation of a gene that is known to inhibit cancer may happen more frequently with cancer of the vulva than with cervical cancer. Researchers conducted a laboratory analysis of eight different types of vulvar cancer and found that the tumor suppressor gene p53 underwent mutation in five of the vulvar cancers. Mutation types included transition, transversion, and deletion. The p53 gene was also damaged by human papillomavirus (HPV) type 16, which breaks down the protein in the gene. Either mutation or HPV damage of the p53 gene may be related to squamous cell cancers of the female lower reproductive tract. Vulvar cancer usually affects older women, and may be caused by the mutations of aging cells.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1995
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