Prevalence of and Risks for Cervical Human Papillomavirus Infection and Squamous Intraepithelial Lesions in Adolescent Girls
Article Abstract:
HIV infection in adolescent girls may enhance active human papillomavirus (HPV) proliferation and the presence of HPV-associated squamous intrepithelial lesions (SILs), even early in the course of HIV infection. HPV has been established as a necessary component in the development of squamous cell cervical cancers. Of 197 adolescent girls tested, the incidence of HPV was 56% among those who were HIV positive and 31% among those who were not infected with the HIV virus. The high prevalence of HPV-associated SILs in the HIV-infected girls suggests that the host immune response may play a significant role in the development of HPV-associated cancers.
Publication Name: Archives of Pediatrics & Adolescent Medicine
Subject: Health
ISSN: 1072-4710
Year: 2000
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T-Lymphocyte Subsets in HIV-Infected and High-Risk HIV-Uninfected Adolescents: Retention of Naive T Lymphocytes in HIV-Infected Adolescents
Article Abstract:
Teenagers who are infected with HIV may have an immune system that is capable of recovering to a greater extent than adults with HIV infection. A study of 192 HIV-positive teenagers found that they experience an increase in naive T cells compared to HIV-negative teenagers. This means that they still have a functional thymus gland and may be capable of producing T cells that can fight the virus. They may also respond better to antiviral drugs and their immune system may recover to a certain extent after treatment.
Publication Name: Archives of Pediatrics & Adolescent Medicine
Subject: Health
ISSN: 1072-4710
Year: 2000
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Risks for Incident Human Papillomavirus Infection and Low-Grade Squamous Intraepithelial Lesion Development in Young Females
Article Abstract:
Cigarette smoking and human papillomavirus infection are the major risk factors for low-grade squamous intraepithelial lesions (LSILs). Any behavioral and biological risk factors for LSILs are most likely risk factors for human papillomavirus infection. LSILs are changes in the cervix that are a benign reaction to the virus.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2001
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