Chemokines are present in the genital tract of HIV-seropositive and HIV-seronegative women: correlation with other immune mediators
Article Abstract:
The levels of chemokines in the female genital tract may indicate immune system activity in the vaginal mucosa that might influence susceptibility to infection with HIV and other sexually transmitted diseases. Researchers measured the powerful chemical mediators in 53 cervicovaginal samples from 41 women infected with or at high risk of HIV. Interleukin-8 was present in 81% of samples. Macrophage inflammatory protein-1 alpha was detected in 15% of samples, and an immune factor called RANTES was found in 32% of samples at levels associated with the inhibition of HIV replication.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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Evaluation of immunologic markers in cervicovaginal fluid of HIV-infected and uninfected women: implications for the immunologic response to HIV in the female genital tract
Article Abstract:
By measuring the cervicovaginal fluids of 19 women, the authors were able to begin establishing bases of measurement reflecting HIV status, menstrual cycle, and genital infection. This may lead to demonstration of times when a women is more receptive to contracting HIV-infection.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
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