Progressive multifocal leukoencephalopathy in a patient treated with natalizumab
Article Abstract:
The clinical course of a patient with multiple sclerosis in whom progressive multifocal leukoencephalopathy (PML), an opportunistic viral infection of the central nervous system, developed during treatment with interferon beta-1a and a selective adhesion-molecule blocker, natalizumab, is described. The patient was treated with systematic cytarabine, and it was found that after two months the patient's condition had improved.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
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Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis
Article Abstract:
Progressive multifocal leukoencephalopathy (PML), a demyelinating disease of the central nervous system (CNS), is associated with high rates of morbidity and mortality and occurs almost exclusively in immunocompromised patients. A trial was conducted to test the safety and efficacy of natalizumab in combination with interferon beta-1a in the treatment of relapsing-remitting multiple sclerosis.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
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Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease
Article Abstract:
The relationship between natalizumab therapy and progressive multifocal leukoencephalopathy (PML), which is an opportunistic, infectious, demyelinating brain disorder associated with impaired T-cell function, is illustrated. Polymavirus replication leading to PML, which is a life threatening disorder, can occur in patients who receive natalizumab.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
User Contributions:
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