Prospective first-trimester screening for trisomy 21 in 30,564 pregnancies

Article Abstract:

The study evaluates the performance of a 1-stop clinic for first-trimester assessment of risk (OSCAR) for trisomy 21 by a combination of maternal age, fetal nuchal translucency (NT) thickness, and maternal serum-free beta-human chorionic gonadotrophin (hCG) and pregnancy-associated plasma protein-A (PAPP-A). It is concluded that the most effective method of screening for chromosomal defects is by first-trimester fetal NT and maternal serum biochemistry.

United States, Science & research, Research, Usage, Chorionic gonadotropin, Chorionic gonadotropins

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Nasal bone in first-trimester screening for trisomy 21

Article Abstract:

The impact of incorporating assessment of the nasal bone into first-trimester combined screening by fetal nuchal translucency (NT) thickness and material serum biochemistry is investigated. Results reveal that the inclusion of the nasal bone in first-trimester combined screening for trisomy 21 achieves a detection rate (DR) of 90% for a false-positive rate (FPR) of 2.5%.

Diagnosis, Medical screening, Health screening, Disease/Disorder overview

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Sonographic screening for trisomy 13 at 11 to 13(super +6) weeks of gestation

Article Abstract:

A study with a purpose to examine the sonographic features of trisomy 13 at 11 to 13 (super +6) weeks of gestation was conducted. At the 11 to 13 (super +6) week scan, the measurement of fetal nuchal translucency and fetal heart rate and fetal examination for holoprosencephaly, exomphalos and megacystic can identify > 90% of fetuses with trisomy 13.

Measurement, Fetal heart rate, Prenatal diagnosis

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