Maternal cell-free viremia in the natural history of perinatal HIV-1 transmission: a meta-analysis
The viral load of HIV in infected pregnant women may predict the likelihood their children will become infected. Researchers analyzed viral loads and disease transmission in 1,115 mother-infant pairs, and found an overall rate of HIV transmission in women not treated with antiviral medication of 21%. Transmission rates varied from 5% to 37% depending on the amount of HIV present in the blood of the women. Women receiving zidovudine appeared to have lower rates of HIV transmission. Women with the lowest viral loads had only a 5% chance of infecting their child, whether or not they were treated.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Heterogeneity of the baseline risk within patient populations of clinical trials
Researchers in this study presented an evaluation algorithm for systematic assessment of the observed heterogeneity in disease risk within trial populations. They used predictive models to estimate the predicted patient hazards and others. The algorithm could also be used for diverse trial comparisons and for designing future pending trials.
Publication Name: American Journal of Epidemiology
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