Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women

Article Abstract:

Estrogen replacement therapy may not lower the risk of heart attack or death in postmenopausal women with coronary heart disease. Researchers randomly assigned 2,763 postmenopausal women with coronary disease to take estrogen plus medroxyprogesterone acetate or a placebo daily. After an average follow-up of 4.1 years, the rate of heart attack or death from coronary heart disease was similar in both groups. This occurred despite the fact that the women on hormone therapy had lower levels of LDL, or 'bad' cholesterol and higher levels of HDL, or 'good' cholesterol.

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Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women

Article Abstract:

Estrogen replacement therapy may not lower the risk of heart attack or death in postmenopausal women with coronary heart disease. Researchers randomly assigned 2,763 postmenopausal women with coronary disease to take estrogen plus medroxyprogesterone acetate or a placebo daily. After an average follow-up of 4.1 years, the rate of heart attack or death from coronary heart disease was similar in both groups. This occurred despite the fact that the women on hormone therapy had lower levels of LDL, or 'bad' cholesterol and higher levels of HDL, or 'good' cholesterol.

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Adherence to National Cholesterol Education Program treatment goals in postmenopausal women with heart disease: The Heart and Estrogen/Progestin Replacement Study (HERS)

Article Abstract:

Many postmenopausal women are not adequately treated for high cholesterol levels. This was the conclusion of a study that measured blood levels of low-density-lipoprotein (LDL), or 'bad' cholesterol, in 2,763 postmenopausal women who had coronary heart disease. About 90% of the women had LDL cholesterol levels over 100 milligrams per deciliter, which is considered an elevated level according to the National Cholesterol Education Program Adult Treatment Panel. This was true even though many women were taking cholesterol-lowering drugs.

Care and treatment, Measurement, Physiological aspects, Postmenopausal women, Blood cholesterol, Hypercholesterolemia

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