Risk factors for HIV-1 shedding in semen
Risk factors for HIV-1 shedding in semen are discussed based on an investigation in 149 men of factors that may be compartment-dependent, the genitourinary tract of the male being immunologically different from blood. Systemic and local genitourinary tract factors influence risk of shedding. Findings indicate that measures of systemic virus burden alone may not be reliably predictive of infectivity of semen.
Publication Name: American Journal of Epidemiology
Lower genitourinary tract sources of seminal HIV
Extensive genitourinary sampling of 23 seropositive men without urethritis who shed HIV in their seminal plasma is conducted to investigate genital tract sources of HIV- 1. Results indicate that distal genitourinary sources other than the prostrate appear to be the major source of seminal HIV in men without clinical urethritis or prostatitis.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
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