Relationship of preoperative antiendotoxin core antibodies and adverse outcomes following cardiac surgery
Measuring the level of IgM antibodies against endotoxin may predict which patients will develop complications from heart surgery. Endotoxin is a component of bacteria and may initiate an inflammatory response in surgical patients. Researchers measured the levels of IgM and IgG antibodies to endotoxin (EndoCAb) in 301 patients before they had heart surgery. Following surgery, 11.3% of the patients developed a complication. Those with low IgM EndoCAb levels were more likely to develop a complication even after adjusting for other risk factors.
Publication Name: JAMA, The Journal of the American Medical Association
Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery
Many patients who have a coronary artery bypass may develop impaired mental function in the years following the operation. In a study of 261 patients who had a bypass, 53% were diagnosed with impaired mental function at discharge, 36% six weeks later, 24% six months later, and 42% five years after surgery.
Publication Name: The New England Journal of Medicine
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