Risk factors for group B streptococcal disease in adults
People older than 65 or those with an identifiable risk factor may be appropriate populations to initially target with a future vaccine developed against group B streptococcal disease. Researchers surveyed 3 urban areas with a total population of 6.6 million people and identified 219 adult cases of group B streptococcal infection. They compared the characteristics of these infected patients with 645 hospital patients admitted for other conditions (controls). Twenty-two percent of the infections were acquired in the hospital. Patients with group B streptococcal infection over the age of 65 were nearly twice as likely to die from the infection as infected patients younger than 65 years of age. Nearly all of the infected patients (93%) had at least one of the identified risk factors including diabetes, breast cancer, stroke, liver cirrhosis, bladder dysfunction, or bed sores.
Publication Name: Annals of Internal Medicine
Geographic diversity and temporal trends of antimicrobial resistance in Streptococcus pneumoniae in the United States
A mathematical transmission model suggests that there is a faster increasing trend in the pneumococcal strains resistant to both penicillin and erythromycin than strains that are singly resistant to either. Data indicate that geographic variation is measured by the selection intensity for resistance.
Publication Name: Nature Medicine
Impact of childhood vaccination on racial disparities in invasive streptococcus pneumoniae infections
The Africans in the United States are more prone to invasive pneumococcal disease than the Americans. There is a decline in invasive disease among the younger children because of the introduction of a new protein polysaccharide pneumococcal conjugate vaccine.
Publication Name: JAMA, The Journal of the American Medical Association
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