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Senescence comes of age

Article Abstract:

Senescent cells in several premalignant or benign conditions are identified and it is demonstrated that the senescence program potently prevents tumorigenesis thereby placing senescence as an equal partner to apoptosis in tumor suppression. The program, designated 'oncogene-induced senescence,' proceeds through the mitogen-activated protein kinase (MAPK) cascade and involves the retionblastom and p53 tumor suppressor pathways.

Aging, Protein kinases, Chemical properties, Aging (Biology)

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Roots and stems: Stem cells in cancer

Article Abstract:

Cancer develops from normal tissues through the accumulation of genetic alterations that act in concert to confer malignant phenotypes. A small population of cells endowed with unique self-renewal properties and tumorigenic potential is present in some, and perhaps all, tumors and the existence of such cells has implications for current conceptualization of malignant transformation and therapeutic approaches to cancer.

Cancer cells, Stem cells

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Telomeres and telomerase: The path from maize, tetrahymena and yeast to human cancer and aging

Article Abstract:

A combination of ingredients and productive collaborations led to the discovery of telomerase in tetrahymena and yeast and sparked research in areas of cellular senescence and cancer. One of the most daunting aspects of addressing the question of the DNA at chromosomal ends was the enormous length of the chromosomal DNAs of eukaryotes.

Eukaryotes, Telomerase

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