Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing

Article Abstract:

The sensitivity of conventional DNA sequencing in tumor biopsies is limited by stromal contamination and genetic heterogeneity within the cancer. Studies show that microreactor-based pyrosequencing can detect rare cancer-associated sequence variations by independent and parallel sampling of multiple representatives of a given DNA fragment. This technology can thereby facilitate accurate molecular diagnosis of heterogeneous cancer specimens and enable patient selection for targeted cancer therapies.

Genetic aspects, Nucleotide sequencing, Tumour removal, Tumor removal

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Cancer researchers usher in dog days of medicine

Article Abstract:

Researchers at the US National Cancer Institute are set to begin drug trials in dogs that aim to bridge the gap between preclinical drug studies and effects of the same drug in people as part of a new comparative-oncology program. Two multicenter trials, set to begin in early 2006 would evaluate new therapeutic approaches for cancer in dogs.

Forecasts, trends, outlooks, Care and treatment, Forecasts and trends, Clinical trials, Diseases, Market trend/market analysis, Dogs, Oncology

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