Sex chromosome composition of complete hydatidiform moles: relationship to metastasis

Article Abstract:

Patients with a hydatidiform mole that is Y chromosome-positive may not have a higher risk of metastatic disease than those with a hydatidiform mole that is Y chromosome-negative. A hydatidiform mole is an abnormal pregnancy that results in a mass of cysts resembling a bunch of grapes. Among 35 patients with hydatidiform moles that were analysed using polymerase chain reaction (PCR), 13 developed metastatic disease and 22 did not. A Y chromosome was found in 8% of the hydatidiform moles from patients with metastatic disease, compared to 9% of those without metastatic disease. The Y chromosome is the male sex chromosome.

Complications and side effects, Sex chromosome abnormalities

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Genetic differentiation of complete hydatidiform moles coexisting with normal fetuses by short tandem repeat-derived deoxyribonucleic acid polymorphism analysis

Article Abstract:

A type of genetic analysis called short tandem repeat-derived deoxyribonucleic acid polymorphism analysis can be used to determine whether a complete hydatidiform molar pregnancy contains a viable fetus. A molar pregnancy occurs when a sperm fertilizes an egg with no nucleus or two sperm fertilize a normal egg. Researchers used this technique on six pregnant women with twin pregnancies, one of which appeared to be a normal fetus and the other a molar pregnancy. The technique revealed normal parental chromosomes in the normal fetus but only paternal chromosomes in the molar pregnancy.

Genetic polymorphisms

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Duration of human chorionic gonadotropin surveillance for partial hydatidiform moles

Article Abstract:

A study was conducted to determine the optimal duration of human chrionic gonadotropin surveillance. The results support the suggestion that a single undetecundetectable human chorionic gonadotropin level after evacuation is sufficient follow-up to ensure remission in patients with partial hydatidiform moles.

United States, Science & research, Health aspects, Research, Chorionic gonadotropin, Chorionic gonadotropins, Pregnancy, Molar, Trophoblastic tumours

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