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Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice

Article Abstract:

The ablation of the mouse Estrogen sulfotransferase (EST), encoded by SULT1E1 gene, that caused placental thrombosis and spontaneous fetal loss phenotype is described. This phenotype was associated with elevated free estrogen levels systematically and in the amniotic fluid, increased tissue factor expression in the placenta and heightened platelet sensitivity to agonist-induced activation ex-vivo.

Genetic aspects, Thrombosis, Placental diseases, Placenta diseases, Blood clot

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Bone loss goes beyond estrogen

Article Abstract:

The role of follicle-stimulating hormone (FSH), which is secreted from the pituitary gland is examined. When ovarian function declines at the menopause, the levels of the ovarian hormones inhibin, and later estrogen, decrease.

Bone resorption, Follicle-stimulating hormone

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A skeleton key to metabolism

Article Abstract:

The bone-specific protein osteocalcin has acted as a hormone that has affected glucose and fat metabolism. The concept of the skeleton as a ductless gland is a revolutionary one.

Proteins, Fat metabolism

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