Stem cell mobilization by beta2-agonists

Article Abstract:

Stem cells are mobilized from the bone marrow to the peripheral blood as a source of stem cells for transplantation in cancer and genetic diseases. The granulocyte colony-stimulating factor (G-CSF) suppresses the expression of CXC ligand 12 through the sympathetic stimulation of the peripheral nervous system and the results suggests that pharmacological intervention with beta2-agonists, drugs commonly used to treat asthma, could be used therapeutically to mobilize stem cells.

Colony-stimulating factors (Physiology), Colony-stimulating factors

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Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction

Article Abstract:

A study to show that the monolayered mesenchymal stem cells have multipotent and self-propagating properties after transplantation into infarcted rat hearts using cell sheet technology was conducted. The monolayered mesenchymal stem cells unlike a fibroblast sheet reversed wall thinning in the scar area and improved cardiac function in rats with myocardial infractions.

Heart attack, Stem cell research

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Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization

Article Abstract:

The role of the Rho GTPases Rac1 and Rac2 in hematopoietic stem cells (HSC) engraftment and mobilization is examined. The deletion of Rac1 after engraftment does not impair steady-state hematopoiesis and is therefore required for the engraftment phase of hematopoietic reconstitution.

Hematopoietic stem cells, Guanosine triphosphatase, GTPases

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