Successful DNA immunization against measles: neutralizing antibody against either the hemagglutinin or fusion glycoprotein protects rhesus macaques without evidence of atypical measles

Article Abstract:

Research presented concerns the development of measles vaccines for the immunization of infants in poor countries. A DNA measles vaccine is studied that protects against the disease without predisposing the patient to a more severe form of the disease, atypical measles.

Statistical Data Included, Physiological aspects, DNA vaccines

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A role for nonprotective complement-fixing antibodies with low avidity for measles virus in atypical measles

Article Abstract:

A formalin-incativated measles vaccine (FIMV) predisposed recipients to atypical measles, an immune complex-mediated disease have been discussed.

Science & research, Analysis, Viral antibodies

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Production of atypical measles in rhesus macaques: evidence for disease mediated by immune e complex formation and eosinophils in the presence of fusion-inhibiting antibody

Article Abstract:

Evidence in macaques for disease mediated by immune complex formation and eosinophils where fusion-inhibiting antibody is present is discussed based on production of atypical measles in the animals. Fusion-inhibiting antibody appeared earlier in these animals than in nonimmunized monkeys. Problems with measles vaccine used in humans are discussed.

Evaluation, Complications and side effects, Diseases, Vaccines, Immunization, Macaques

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