Cyclophosphamide-induced cystitis and bladder cancer in patients with Wegener granulomatosis

Article Abstract:

Long-term treatment with cyclophosphamide may increase the risk of inflammation and cancer of the bladder in people with Wegener granulomatosis. Cyclophosphamide is often used to treat Wegener granulomatosis, which involves the inflammation of blood vessels and the death of tissue. A total of 145 people who took cyclophosphamide for Wegener granulomatosis were followed for 0.5 to 27 years. Of these people, 73 (50%) had blood in their urine primarily caused by bladder inflammation. Among 60 of these people, 42 (70%) appeared to have an bladder injury caused by cyclophosphamide, based on examination of their bladders. Seven (5%) of the people receiving cyclophosphamide developed bladder cancer. Most of these people with cancer previously had blood in their urine and had taken more than a total of 100 milligrams of cyclophosphamide. Statistical analysis suggested that blood in the urine was associated with an increased risk for bladder cancer among this population.

Risk factors, Drug therapy, Bladder cancer, Cystitis, Wegener's granulomatosis

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Use of testosterone to prevent cyclophosphamide-induced azoospermia

Article Abstract:

The addition of testosterone therapy to treatment with cyclophosphamide chemotherapy may protect male patients' long-term fertility. Testosterone was added to five of 15 male patients' cyclophosphamide chemotherapy and sperm counts were done before, during, and six months after eight months of treatment. All patients had a zero sperm count during treatment. Sperm counts returned to normal levels six months after treatment among all patients taking additional testosterone. Only one of 10 patients' sperm counts returned to normal among the patients not taking testosterone.

Health aspects, Care and treatment, Testosterone, Spermatogenesis, Infertility, Male, Male infertility

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