Mice without telomerase: what can they teach us about human cancer?

Article Abstract:

This article discusses recent research findings linking telomere activity and growth or arrest of growth of primary cells to cancer initiation and or progression. However, available data point out that a complete understanding requires analysis of human tumors and cell culture studies and verifying the results with an experimental model organism.

Author: DePinho, Ronald A., Artandi, Steven E.
Aging, Physiological aspects, Telomeres, Carcinogenesis, Telomerase

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Gazing into a crystal ball - cancer therapy in the post-genomic era

Article Abstract:

How an understanding of genetic sequencing may affect individual cancer therapy is examined. Topics include possibilities for sequencing a patient's entire genome, principles to consider when forecasting the impact of medical research, and challenges to be overcome before genome sequencing can be fully utilized in cancer therapy.

Author: Ratain, Mark J., Relling, Mary V.
Cancer, Cancer genetics, Oncology

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Subjects list: United States, Genetic aspects
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