The effect of tamoxifen and transdermal 17beta-estradiol on cerebral arterial vessels: a randomized controlled study
Article Abstract:
More research is needed before tamoxifen can be recommended as a drug that could lower a woman's risk of heart disease. Tamoxifen has some of the same properties as estrogen and is typically used to treat breast cancer. Researchers randomly assigned 45 healthy postmenopausal women to take take estrogen in the form of estradiol, tamoxifen or a placebo. Doppler ultrasound was used to measure blood flow in the women's carotid and cerebral arteries at various times during one year. Estradiol lowered the resistance to blood flow but tamoxifen did not. Thus tamoxifen may not benefit the heart as much as estrogen does.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1998
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Alteration in the pulsatility index values of the internal carotid and middle cerebral arteries after suspension of postmenopausal hormone replacement therapy: a randomized crossover study
Article Abstract:
Stopping hormone replacement therapy appears to significantly affect blood flow in women previously taking the therapy. Evidence indicates that hormone replacement therapy should be continuous to maintain the protective effect against heart disease seen in some women. Blood flow in the major neck artery and several brain arteries was measured in 23 postmenopausal women during six months of hormone therapy and six months of no therapy. Blood flow measurements increased during the six-month period with no therapy and returned to previously stable values when therapy resumed.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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Tamoxifen, esterified estradiol, and physiological concentrations of estradiol inhibit oxidation of low-density lipoprotein by endothelial cells
Article Abstract:
Estradiol and tamoxifen both prevent the oxidation of low-density lipoprotein inside blood vessels. This could explain why women have a lower rate of heart disease than men. Lipid oxidation is believed to be one of the factors that causes atherosclerosis.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2001
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