Reperfused and nonreperfused myocardial infarction: diagnostic potential of Gd-DTPA-enhanced MR imaging
Article Abstract:
In a myocardial infarction (MI or heart attack) there is damage to the heart muscle due to decreased oxygen supply following the occlusion of one or more coronary arteries. It is important to identify those areas of the myocardium (heart muscle) that can be reperfused with blood (recover normal circulation) and salvaged. Magnetic resonance (MR) imaging, in conjunction with the use of the contrast agent gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA), was used with 45 patients suspected of suffering from acute MI. This technique is being evaluated in order to identify those areas of heart muscle that might respond to coronary thrombolytic (clot preventing) therapy as a means of salvaging jeopardized myocardial tissue. Researchers are attempting to assess the differences between normal and infarcted myocardial tissue at different times following the injection of Gd-DTPA. Thus far results have not been encouraging. Gd-DTPA enhanced MR imaging did not appear to reflect the degree of reperfusion that took place. Different patterns of Gd-DTPA distribution were observed in reperfused and nonreperfused infarcts. Researchers advocate further investigation into the value of Gd-DTPA distribution patterns in the assessment of reperfusion and nonreperfusion of myocardial tissue.
Publication Name: Radiology
Subject: Health
ISSN: 0033-8419
Year: 1989
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Whole-body lymphangioscintigraphy: preferred method for initial assessment of the peripheral lymphatic system
Article Abstract:
This study presents the use of an improved radionuclide imaging technique for diagnosing congenital and acquired lymphedema, or swelling of the lymph glands, in either the upper or lower extremities. A digital gamma camera, in conjunction with the intradermal injection of radioactive technetium-99m (Tc-99m), was employed as a means of accomplishing whole-body lymphangioscintigraphy (LAS). There are limitations to the technique, however. Detailed assessment of lymph node structures, specifically those associated with primary or metastatic malignancy, is not possible with LAS. Such information, after screening with LAS, is best depicted by conventional lymphography or with computed tomography (CT). LAS best illustrates peripheral lymphatic anatomy and function below the groin or armpit.
Publication Name: Radiology
Subject: Health
ISSN: 0033-8419
Year: 1989
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