The neglected ion: HCO3

Article Abstract:

Issues related to the genetic causes for cystic fibrosis are examined, focusing on research on the cystic fibrosis transmembrance conductance reguator (CFTR). Topics include previous concentration by researchers on the interruption of the CL- ion transport in CFTR mutations, failure to explain important symptoms of CF in terms of the Cl- ion, and findings that indicate research of the HCO3- anions may provide further understanding of CF pathogenesis.

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Finally, mice with CF lung disease

Article Abstract:

Overexpressing the epithelial sodium channel increases sodium absorption in mouse airways that results in mucus accumulation and inflammation changes occurring in the lungs of individuals with . It is believed that insights into a disease that was long since lacking an animal model can be provided through the development of lung disease in these mice.

Mucus

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Increased airway epithelial Na(super +) absorption produces cystic fibrosis-like lung disease in mice

Article Abstract:

Defective epithelial cAMP-dependant Cl(super -) secretion and increased airway Na(super +) absorption are caused due to mutation in cystic fibrosis transmembrane conductance regulator (CFTR) gene. It is concluded that increasing airway Na(super +) absorption initiates cystic fibrosis-like lung disease and produces a model for study of pathogenesis.

Gene mutations, Gene mutation

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