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The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

Article Abstract:

Research indicates that the hepatocyte nuclear factor-4alpha regulates coordinate nuclear-receptor-mediated response to xenobiotics and that it is involved in the PXR- and CAR-mediated gene activation, which in turn regulate the cytochrome P450 3A4 (CYP3A4) expression, a drug metabolizing enzyme.

Author: Duncan, Stephen A., Kim, Richard B., Gonzalez, Frank J., Tirona, Rommel G., Lee, Wooin, Leake, Brenda F., Lan, Lu-Bin, Cline, Cynthia Brimer, Lamba, Vishal, Parviz, Fereshteh, Inoue, Yusuke, Schuetz, Erin G.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Physiological aspects, Metabolic regulation, Xenobiotics, Drug metabolism, Drug receptors

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Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis

Article Abstract:

The contribution of peroxisome proliferator-activated receptor--delta (PPAR-delta) is unclear in colon cancer and is expressed at high level in colon tumors. It is shown that colon carcinogenesis is attenuated through PPAR-delta.

Author: Gonzalez, Frank J., Harman, Fred S., Nicol, Christropher J., Marin, Holly E., Ward, Jerrold M., Peters, Jeffrey M.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
Diagnosis, Carcinogenesis, Colorectal diseases, Colonic diseases

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Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth

Article Abstract:

Results of a study provide the first evidence that Peroxisome proliferator-activated receptor-delta (PPAR-delta) activation promotes the growth of intestinal adenomas. Effects on polyp size and other factors are discussed.

Author: Gupta, Rajnish A., Wang, Dingzhi, Katkuri, Sharada, Wang, Haibin, Dey, Sudhansu, K.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
Causes of, Adenoma

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Subjects list: United States, Research, Peroxisomes
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