Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia
Article Abstract:
A study is conducted to assess the association of thiopurine methyltransferase (TPMT) genotype with minimal residual disease load before and after treatment with mercaptopurine in the early treatment course of childhood acute lymphoblastic leukemia. The results support the role for minimal residual disease analyses in the assessment of genotype-phenotype associations in multiagent chemotherapeutic trials.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2005
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Speech, language, and reading skills after early cochlear implantation
Article Abstract:
The age at which cochlear implantation or duration of implant use is associated with speech, language, and reading skills exhibited at age 8 to 9 years in children who underwent implantation by age 5 years is examined. It is concluded that greater speech and language proficiency may be expected from children who exhibit normal hearing for even a brief period after birth.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2004
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Early detection vs late treatment of amblyopia
Article Abstract:
The effectiveness of treatment of amblyopia in children aged 7 to 17 years is examined. The results suggested that amblyopia improves with optical correction alone in about one forth of patients aged 7 to 17 years although most patients who are initially treated with optical correction alone would require additional treatment for amblyopia.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2005
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