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Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: a mechanism for cellular human immunodeficiency virus 1 infection

Article Abstract:

Research presented concerns the role of CD4 cells and the chemokine receptor CCR5 in the transmission and propagation of human immunodeficiency virus- 1 (HIV-1). Topics addressed include CCR5 microparticles, and the binding of these microparticles to other cells.

Author: Nelson, Peter J., Mack, Matthias, Kleinschmidt, Andrea, Bruhl, Hilke, Klier, Christiane, Cihak, Josef, Plachy, Jiri, Stangassinger, Manfred, Erfle, Volker, Schlondorff, Detlef
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
T cells, Cytokines

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Suppression of CCR5- but not CXCR4-trophic HIV-1 in lymphoid tissue by human herpesvirus 6

Article Abstract:

This study examines the interaction between HIV-1 and human herpesvirus 6 in infected lymphoid tissue, focusing on how the herpesvirus impacts HIV-1 replication levels. Research suggests that HHV-6 replication may suppress CCR5-utilizing HIV-1 variants, but not impact replication of CXCR4-trophic variants.

Author: Grivel, Jean-Charles, Yoshinori, Ito, Faga, Giovanni, Santoro, Fabio, Shaheen, Farida, Malnati, Mauro S., Fitzgerald, Wendy, Lusso, Paolo, Margolis, Leonid
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Italy, United States, Development and progression, AIDS (Disease), CD4 lymphocytes, Herpesvirus diseases, Herpesvirus infections

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Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease

Article Abstract:

Research demonstrates that human interleukin-4 therapy for patients with severe psoriasis is effective and within six weeks the patients show reduced clinical scores with majority of them improving more than 68%. Data indicate that the therapy induces Th2 differentiation in CD4*T cells, suggesting to its efficacy in the treatment of the Th1-associated autoimmune disease psoriasis.

Author: Mack, Matthias, Schlondorff, Detlef, Plewig, Gerd, Rocken, Martin, Ghoreschi, Kamran, Thomas, Peter, Breit, Susanne, Dugas, Martin, Mailhammer, Reinhard, van Eden, Willem, van der Zee, Ruurd, Biedermann, Tilo, Prinz, Jorg, Mrowietz, Ulrich, Christophers, Enno, Sander, Christian A.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Netherlands, Physiological aspects, Drug therapy, Autoimmune diseases, Inflammation, Drug use, Psoriasis, Interleukin-4

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Subjects list: Statistical Data Included, Research, Germany, HIV infection, HIV infections, HIV (Viruses), HIV
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