Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: a mechanism for cellular human immunodeficiency virus 1 infection
Article Abstract:
Research presented concerns the role of CD4 cells and the chemokine receptor CCR5 in the transmission and propagation of human immunodeficiency virus- 1 (HIV-1). Topics addressed include CCR5 microparticles, and the binding of these microparticles to other cells.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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Suppression of CCR5- but not CXCR4-trophic HIV-1 in lymphoid tissue by human herpesvirus 6
Article Abstract:
This study examines the interaction between HIV-1 and human herpesvirus 6 in infected lymphoid tissue, focusing on how the herpesvirus impacts HIV-1 replication levels. Research suggests that HHV-6 replication may suppress CCR5-utilizing HIV-1 variants, but not impact replication of CXCR4-trophic variants.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease
Article Abstract:
Research demonstrates that human interleukin-4 therapy for patients with severe psoriasis is effective and within six weeks the patients show reduced clinical scores with majority of them improving more than 68%. Data indicate that the therapy induces Th2 differentiation in CD4*T cells, suggesting to its efficacy in the treatment of the Th1-associated autoimmune disease psoriasis.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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