Transient high titers of HIV-1 in plasma and progression of disease
Article Abstract:
Periods of high levels of HIV in blood may be associated with progression and symptoms of the disease. Researchers studied the presence of HIV in the blood of 28 HIV-positive people who had CD4 cell counts of 300 or less. Some patients experienced brief periods of high levels of HIV in their blood. These periods were associated with such symptoms as fever, rash, and infections associated with a weakened immune system. CD4 cell counts of 50 or less and declining CD4 cell counts were also associated with high blood levels of the virus. The syncytium-inducing strain of HIV was often found during these periods. Identifying the reason for these spikes in blood levels of HIV may increase understanding of disease progression.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Effects of reverse transcriptase inhibitor therapy on the HIV-1 viral burden in semen
Article Abstract:
Drug treatment for HIV infection may reduce the amount of virus in semen. Researchers measured HIV RNA in blood and semen samples of 11 HIV-infected men before and after they began treatment with reverse transcriptase inhibitors such as zidovudine. In 82% of the men, levels of HIV in semen dropped after treatment. Five of the men were followed for at least a year and their semen HIV levels continued to be below the level measured before treatment. In much of the world, sexual intercourse is the primary means of HIV transmission.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Protease inhibitor and nonnucleoside reverse transcriptase inhibitor concentrations in the genital tract of HIV-1-infected women
Article Abstract:
The pharmacokinetics of antiretovials (ARVs) in the female genital tract (FGT) are likely to influence vertical and sexual transmission of HIV, the development of viral resistance, and postexposure regimens. The large differences in cervicovaginal fluid (CVF) penetration suggests that further research into ARV phamacokinetics and drug efficacy in the FGT is necessary.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Transforming growth factor beta2 in labial salivary glands in Sjogren's syndrome. Neutral endopeptidase (EC 3.4.24.11) in labial salivary glands in healthy controls and in patients with Sjogren's syndrome
- Abstracts: CCR5 chemokine receptor variant in HIV-1 mother-to-child transmission and disease progression in children. Morbidity and mortality in European children vertically infected by HIV-1
- Abstracts: Zidovudine resistance, syncytium-inducing phenotype, and HIV diseases progression in a case-control study. Changes in plasma HIV RNA levels and CD4+ lymphocyte counts predict both response to antiretroviral therapy and therapeutic failure
- Abstracts: Medical Futility in End-of-Life Care. Medical professionalism in society. Crisis, ethics, and the American Medical Association: 1847 and 1997
- Abstracts: Benefits of new legislation for moving and handling: trusts are getting the message that the right equipment is a better option than paying compensation for work injuries