Trauma and seronegative spondyloarthropathy: report of two more cases of peripheral arthritis precipitated by physical injury
Article Abstract:
Histocompatibility antigens (HLA), present on all cells with a nucleus, can activate the immune system and their expression is controlled by a specialized set of genes called the major histocompatibility gene complex (MHC). The HLA-B27 type can be detected in patients with arthritis, an inflammatory joint disease. Previous reports have described two cases of patients with HLA-B27 who developed arthritis after a traumatic event. In contrast to other patients with peripheral arthritis, these HLA-B27-positive patients showed rapid and severe deterioration, requiring complete hip replacement. Two more cases are described of patients with HLA-B27-related peripheral arthritis caused by a physical injury. A 41-year-old man was run over by a car, and suffered several bruises and a fractured hand. He underwent surgery to repair his right hand, but later developed Reiter's syndrome, consisting of diarrhea, fever, inflammation of the urethra, and arthritis. The patient had a history of inflammation, stiffness and pain. The inflammation of the urethra and diarrhea resolved without treatment, and the arthritis was treated with diclofenac, an anti-inflammatory agent. In the second case, a 25-year-old man developed arthritis in both knees after landing incorrectly during a parachute jump. He had no history of inflammatory disease, but was positive for HLA-B27. The patient was treated with steroids and recovered within two months. The mechanisms whereby injury causes arthritis in HLA-B27-positive persons are not known. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1989
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Urticaria/arthritis syndrome: report of four B51 positive patients
Article Abstract:
Urticaria is a blood vessel reaction of the skin characterized by the eruption or outbreak of pale, transient wheals, or elevations of the skin, which are associated with severe itching. Joint disease may occur in long-term urticaria, although it is not clear whether joint disease and urticaria share similar pathogenetic mechanisms. Cases are described of four patients with urticaria and joint disease, but without evidence of immune complex-mediated disease. Immune complexes consist of specialized proteins called antibodies bound to foreign particles called antigens. Under abnormal conditions, immune complexes may contribute to disease processes such as inflammation in rheumatoid arthritis, an inflammatory joint disease. Patients with urticaria and joint disease share in common a specific type of genetic element, the histocompatibility antigens (HLA), which are present on all cells with a nucleus. HLA are capable of activating the immune system and are controlled by a specialized set of genes called the major histocompatibility gene complex (MHC). HLA-B51 antigen was detected in all patients with both urticaria and joint disease, suggesting a common genetic background shared by patients with urticaria and joint disease. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1989
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Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) syndrome: a prospective follow up and magnetic resonance imaging study
Article Abstract:
The similarities between remitting seronegative symmetrical synovitis with pitting edema (RS3PE) and polymyalgia rheumatica (PMR) are striking enough to suggest that both conditions are part of the same disease. If so, the presence of a distal edema seems to indicate a better prognosis for the patient. Using magnetic resonance to do a prospective follow up of 23 patients showing RS3PE symptoms and 177 with PMR, the similarities between the two were enough to suggest the two were the same disease. The rimary difference was that those with pure RS3PE symptoms, responded faster to medication, required less treatment and had lower incidence of relapse.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1999
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