Tweaking liver progenitor cells

Article Abstract:

Two proteins that include TWEAK, a TNF family ligand and LIGHT, an important ligand for hepatocyte replication are identified that target oval cells prompting them to proliferate. Regardless of adding complexities, the identification of TWEAK and LIGHT as new players in oval-cell and hepatocyte replication offers new clues to the regulation of cellular responses in liver growth processes.

Author: Fausto, Nelson
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Liver & Kidney R&D, Liver cells, Hepatocytes, Liver research

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA

Hepatitis C virus replication in mice with chimeric human livers

Article Abstract:

Development of antiviral therapies against hepatitis C virus (HCV) was impeded due to the lack of a small animal model of the human hepatitis C virus. With a view to overcome this problem a chimeric mice is represented as the first murine model suitable for studying the human hepatitis C virus in vivo.

Author: Kneteman, Norman M., Mercer, David F., Schiller, Daniel E., Elliott, John F., Douglas, Donna N., Hao, Chunhai, Rinfret Aline, Addison, William R., Fischer, Karl P, Churchill, Thomas A, Lakey, Jonathan R.T, Tyrrell, David L.J
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA

A mouse model for hepatitis C virus infection?

Article Abstract:

Highest proportion of liver transplantation is carried out on patients with hepatitis C. The report of infection of a mouse model with the hepatitis C virus is presented with a view to understand how hepatitis C and liver damage develop and in testing possible treatments to.

Author: Fausto, Nelson
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Liver, Liver transplantation

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Subjects list: Research, Care and treatment, United States, Hepatitis C virus
This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.