Two worlds of malaria

Article Abstract:

There are different types of malaria depending on which parasite infects a person. Plasmodium is the name of the parasite that causes malaria, but there are four types of Plasmodium. One type lives predominantly in blood and can be easily killed by drugs. The other type lives in the liver, and may not cause symptoms for months and even years. Some malaria drugs may no be effective against this type of Plasmodium.

Author: Miller, Louis H., Wellems, Thomas E.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2003
Prognosis

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Return of chloroquine antimalarial efficacy in Malawi

Article Abstract:

A randomized clinical trial was conducted involving 210 children with uncomplicated Plasmodium falciparum malaria in Blantyre, Malawi by treating the children either with chloroquine or sulfadoxine-pyrimethamine to assess the antimalarial efficacy of the drug. Chloroquine was again found to be an efficacious treatment for malaria, 12 years after it was withdrawn from use in Malawi.

Author: Plowe, Christopher V., Taylor, Terrie E., Laufer, Miriam K., Thesing, Phillip C., Eddington, Nicole D., Masonga, Rhoda, Dzinjalamala, Fraction K., Takala, Shannon L.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
Pharmaceutical Preparation Manufacturing, Antimalarial & Antifungal Preps, Malawi, Antimalarials, Clinical report

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A molecular marker for chloroquine-resistant falciparum malaria

Article Abstract:

A mutation in the pfcrt gene of Plasmodium falciparum could be used to determine whether the organism is resistant to chloroquine. Plasmodium falciparum is the organism that causes malaria. Chloroquine is one of the most common drugs used to prevent and treat malaria, but the organism is becoming resistant to it, particularly in sub-Saharan Africa.

Author: Djimde, Abdoulaye, Doumbo, Ogobara K., Cortese, Joseph F., Kayentao, Kassoum, Doumbo, Safi, Diourte, Yacouba, Dicko, Alassane, Su, Xin-Zhuan, Nomura, Takashi, Fidock, David A., Wellems, Thomas E., Plowe, Christopher V.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2001
Health aspects, Drug resistance in microorganisms, Microbial drug resistance, Identification and classification

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Subjects list: Patient outcomes, Drug therapy, Malaria, Plasmodium falciparum, Chloroquine
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