Rectal microbicides for U.S. gay men: are clinical trials needed?
Many gay men may be willing to participate in clinical trials of rectal microbicides. Microbicides are chemicals that kill bacteria and viruses, such as HIV. A survey of 2,216 gay men who practiced anal intercourse found that 20% never used a condom. Most of the men used anal lubricants and many bought products containing nonoxynol-9. Nonoxynol-9 was developed to kill sperm but its effectiveness as a microbicide has not been established. Two-thirds of the men indicated that they would be willing to participate in clinical trials of microbicides.
Publication Name: Sexually Transmitted Diseases
Negative results on a quantitative latex D-dimer test exclude deep leg clots
A blood test that looks for breakdown products from blood clots can be used to identify patients who probably do not have deep vein thrombosis, according to a study of 556 patients. In 283 patients, the test showed no breakdown products and only one of these patients was found by further testing to have abnormal blood clots. Deep vein thrombosis occurs when abnormal blood clots form in the large veins in the legs.
Publication Name: Annals of Internal Medicine
- Abstracts: Clozapine treatment of schizophrenia. Effectiveness and cost of olanzapine and haloperidol in the treatment of schizophrenia: a randomized controlled trial
- Abstracts: Risk factors for deep venous thrombosis of the upper extremities. Cost of long-term complications of deep venous thrombosis of the lower extremities: an analysis of a defined patient population in Sweden
- Abstracts: Comparison of the effects of over-the-counter famotidine and calcium carbonate antacid on postprandial gastric acid: a randomized controlled trial
- Abstracts: Enhanced deoxyribonucleic acid damage and repair but unchanged apoptosis in uterine leiomyomas treated with gonadotropin-releasing hormone agonist. part 2
- Abstracts: Ethical complexities of conducting research in developing countries. Ethical issues in studies in Thailand of the vertical transmission of HIV