Ultrastructural study of Helicobacter pylori-associated gastritis

Article Abstract:

Helicobacter pylori has recently been associated with the development of gastritis and peptic ulcers in man. The mechanism of pathogenicity or the basis of virulence of this bacteria has not been clearly identified. Biopsies of stomach mucosal tissue were taken from 26 patients with H. pylori-associated gastritis before and after treatment. Tissue sections were variably fixed for scanning (SEM) or transmission (TEM) electron microscopic analysis. SEM observations, which were confirmed by TEM, showed the entrapment and concentration of H. pylori in intercellular areas of epithelial cells. In areas where H. pylori was concentrated, there was a reduction in the number of microvilli observed. There was also a depletion of mucous granules and degenerative changes in the epithelial cells. The close adherence of H. pylori cells to the mucosal cell membrane produced cup-shaped depressions on the cell surfaces. Occasionally, epithelial cell surfaces were entirely disrupted and H. pylori cells were observed in the cytoplasm and cytoplasmic vacuoles. Examination of post-treatment biopsy tissue specimens showed restoration of the normal cellular structure of the gastric mucosa. This provides further evidence for the pathogenic role of H. pylori in the development of gastritis. (Consumer Summary produced by Reliance Medical Information, Inc.)

Analysis, Causes of, Development and progression, Helicobacter pylori, Helicobacter infections, Gastritis

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Pseudocysts of the mandibular condyle in children

Article Abstract:

Pseudocysts around the jaw bone seem to occur as frequently in children as in adults. This suggests they are genetic and not environmental, and may be no more than variations in the anatomy distorted by panoramic X-rays, appearing as dark areas. In a study of 599 girls and 594 boys aged 3.3 to 18.7 years, 1.5% had pseudocysts compared to 1.8% in the adult population. Follow-up on 11 of these patients from one to three years later showed minimal change in size, reinforcing the genetic probability. Dentists who see these pseudocysts should consider them normal and make a follow-up image four to six months later to confirm this diagnosis.

Evaluation, Abnormalities, Diagnosis, Radioscopic, Radioscopic diagnosis, Mandible, Temporomandibular joint

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