Unmet expectations: the brain minds

Article Abstract:

Research shows that the levels of a subunit of alpha-amino-3-hydroxy-5-methyl-4-isoxazol propionate glutamate receptors in the nucleus accumbens undergo changes during drug usage and drug withdrawal phases. Data indicate that in addition to the effect of drugs on the brain's reward circuitry, frustration of not taking it when they are anticipated can also affect the reward circuits.

Author: Wise, Roy A., Carlezon, William A. Jr.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Science & research, Drug withdrawal symptoms, Substance withdrawal syndrome, Brain chemistry

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The vicious cyclin of addiction

Article Abstract:

Neurobiological research on drug addiction is presented, focusing on how addiction is associated with neural and behavioral plasticity. DNA microarray analysis is used to study how chronic cocaine exposure is linked with a cyclin-dependent kinase that changes striatal dopamine-receptor signaling.

Author: White, Francis J., Cooper, Donald C.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Cocaine

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The cellular neurobiology of depression

Article Abstract:

Research in neurobiology finds a link between mental depression disorders and problems with the signaling pathways involved in the regulation of cell survival and neuroplasticity. Researchers suggest that drugs designed to modify molecules in the signaling pathways may be of therapeutic value.

Author: Manji, Husseini, Drevets, Wayne C., Charney, Dennis S.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Depression, Mental, Depression (Mood disorder)

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Subjects list: Research, United States, Physiological aspects, Cellular signal transduction, Drug abuse, Neurobiology, Neuroplasticity
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